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1

Activation of Vinyl Iodides for the Highly Enantioselective Addition to Aldehydes

Dr. Albert M. DeBerardinis, Mark Turlington, Prof. Lin Pu

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 249 KB

english, 2011

2

Activation of Vinyl Iodides for the Highly Enantioselective Addition to Aldehydes

Dr. Albert M. DeBerardinis, Mark Turlington, Prof. Lin Pu

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 238 KB

english, 2011

3

ChemInform Abstract: Highly Enantioselective Catalytic Alkyl Propiolate Addition to Aliphatic Aldehydes.

Mark Turlington, Albert M. DeBerardinis, Lin Pu

Journal:

Year:

2009

File:

PDF, 30 KB

2009

4

ChemInform Abstract: 3,3′-Anisyl-Substituted BINOL, H4BINOL, and H8BINOL Ligands: Asymmetric Synthesis of Diverse Propargylic Alcohols and Their Ring-Closing Metathesis to Chiral Cycloalkenes.

Yang Yue, Mark Turlington, Xiao-Qi Yu, Lin Pu

Journal:

Year:

2010

Language:

english

File:

PDF, 74 KB

english, 2010

5

ChemInform Abstract: Facile Synthesis of a Family of H8BINOL-Amine Compounds and Catalytic Asymmetric Arylzinc Addition to Aldehydes.

Albert M. DeBerardinis, Mark Turlington, Jason Ko, Laura Sole, Lin Pu

Journal:

Year:

2010

File:

PDF, 36 KB

2010

6

ChemInform Abstract: Highly Enantioselective Addition of Linear Alkyl Alkynes to Linear Aldehydes.

Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu

Journal:

Year:

2011

File:

PDF, 39 KB

2011

7

ChemInform Abstract: Catalytic Asymmetric Synthesis of Chiral Propargylic Alcohols for the Intramolecular Pauson—Khand Cycloaddition.

Mark Turlington, Yang Yue, Xiao-Qi Yu, Lin Pu

Journal:

Year:

2011

File:

PDF, 62 KB

2011

8

ChemInform Abstract: Activation of Vinyl Iodides for the Highly Enantioselective Addition to Aldehydes.

Albert M. DeBerardinis, Mark Turlington, Lin Pu

Journal:

Year:

2011

File:

PDF, 32 KB

2011

9

ChemInform Abstract: From Highly Enantioselective Catalytic Reaction of 1,3-Diynes with Aldehydes to Facile Asymmetric Synthesis of Polycyclic Compounds.

Mark Turlington, Yuhao Du, Samuel G. Ostrum, Vishaka Santosh, Kathryne Wren, Tony Lin, Michal Sabat, Lin Pu

Journal:

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

10

ChemInform Abstract: Reverse the Diastereoselectivity of the Rh(I)-Catalyzed Pauson—Khand Cycloaddition.

Mark Turlington, Lin Pu

Journal:

Year:

2011

File:

PDF, 35 KB

2011

11

Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin

Toni Brown, Zarmeen Taherbhai, Jim Sexton, Arden Sutterfield, Mark Turlington, Justin Jones, Lindsay Stallings, Michelle Stewart, Karen Buchmueller, Hilary Mackay, Caroline O’Hare, Jerome Kluza, Binh

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

12

Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm

Toni Brown, Hilary Mackay, Mark Turlington, Arden Sutterfield, Traci Smith, Alan Sielaff, Laura Westrate, Chrystal Bruce, Jerome Kluza, Caroline O’Hare, Binh Nguyen, W. David Wilson, John A. Hartley,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 2.10 MB

english, 2008

13

Highly enantioselective addition of linear alkyl alkynes to linear aldehydes

Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 1.74 MB

english, 2010

14

Targeting Selective Activation of M 1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M 1 Positive Allosteric Modulator ML169

Tarr, James C., Turlington, Mark L., Reid, Paul R., Utley, Thomas J., Sheffler, Douglas J., Cho, Hyekyung P., Klar, Rebecca, Pancani, Tristano, Klein, Michael T., Bridges, Thomas M., Morrison, Ryan D.

Journal:

ACS Chemical Neuroscience

Year:

2012

Language:

english

File:

PDF, 1.27 MB

english, 2012

15

ChemInform Abstract: Asymmetric Alkyne Addition to Aldehydes Catalyzed by BINOL and Its Derivatives

Mark Turlington, Lin Pu

Journal:

Year:

2012

File:

PDF, 18 KB

2012

16

Characterization of Novel Synthesized Small Molecular Compounds Against Non-Small Cell Lung Cancer

Yunge Zhao, Mark Turlington, Damien J. LaPar, David R. Jones, David A. Harris, Irving L. Kron, Lin Pu, Christine L. Lau

Journal:

The Annals of Thoracic Surgery

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

17

Study of the Fluorescent Properties of Partially Hydrogenated 1,1′-Bi-2-naphthol-amine Molecules and Their Use for Enantioselective Fluorescent Recognition

Yu, Shanshan, DeBerardinis, Albert M., Turlington, Mark, Pu, Lin

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

18

Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Jacobs, Jon, Grum-Tokars, Valerie, Zhou, Ya, Turlington, Mark, Saldanha, S. Adrian, Chase, Peter, Eggler, Aimee, Dawson, Eric S., Baez-Santos, Yahira M., Tomar, Sakshi, Mielech, Anna M., Baker, Susan

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.74 MB

english, 2013

19

3,3′-Anisyl-Substituted BINOL, H 4 BINOL, and H 8 BINOL Ligands: Asymmetric Synthesis of Diverse Propargylic Alcohols and Their Ring-Closing Metathesis to Chiral Cycloalkenes

Yue, Yang, Turlington, Mark, Yu, Xiao-Qi, Pu, Lin

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 1.25 MB

english, 2009

20

Highly Enantioselective Catalytic Alkyl Propiolate Addition to Aliphatic Aldehydes

Turlington, Mark, DeBerardinis, Albert M., Pu, Lin

Journal:

Organic Letters

Year:

2009

Language:

english

File:

PDF, 144 KB

english, 2009

21

From Highly Enantioselective Catalytic Reaction of 1,3-Diynes with Aldehydes to Facile Asymmetric Synthesis of Polycyclic Compounds

Turlington, Mark, Du, Yuhao, Ostrum, Samuel G., Santosh, Vishaka, Wren, Kathryne, Lin, Tony, Sabat, Michal, Pu, Lin

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

22

Catalytic Asymmetric Synthesis of Chiral Propargylic Alcohols for the Intramolecular Pauson−Khand Cycloaddition

Turlington, Mark, Yue, Yang, Yu, Xiao-Qi, Pu, Lin

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

23

Facile Synthesis of a Family of H 8 BINOL-Amine Compounds and Catalytic Asymmetric Arylzinc Addition to Aldehydes

DeBerardinis, Albert M., Turlington, Mark, Ko, Jason, Sole, Laura, Pu, Lin

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

24

Total Synthesis of Stemaphylline N -Oxide and Related C9a-Epimeric Analogues

Schulte, Michael L., Turlington, Mark L., Phatak, Sharangdhar S., Harp, Joel M., Stauffer, Shaun R., Lindsley, Craig W.

Journal:

Chemistry - A European Journal

Year:

2013

Language:

english

File:

PDF, 794 KB

english, 2013

25

Activation of Functional Arylzincs Prepared from Aryl Iodides and Highly Enantioselective Addition to Aldehydes

DeBerardinis, Albert M., Turlington, Mark, Pu, Lin

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 116 KB

english, 2008

26

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Turlington, Mark, Chun, Aspen, Tomar, Sakshi, Eggler, Aimee, Grum-Tokars, Valerie, Jacobs, Jon, Daniels, J. Scott, Dawson, Eric, Saldanha, Adrian, Chase, Peter, Baez-Santos, Yahira M., Lindsley, Craig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.93 MB

english, 2013

27

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 995 KB

english, 2014

28

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu 5 )

Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T., Noetzel, Meredith J., Vinson, Paige N., Jadhav, Satyawan, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, Jos

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

29

Alternative synthetic routes to N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) and other triazolinedione derivatives

Breton, Gary W., Turlington, Mark

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 453 KB

english, 2014

30

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu 5 ) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)- N -(3-methyloxetan-3-yl)picolinamide (ML254)

Turlington, Mark, Noetzel, Meredith J., Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D., Nguyen, Elizabeth D., Gregory, Karen J., Vinson, Paige N., Rook, Jerri M., Gogi, Kiran K., Xiang, Zixiu, Bridges, Th

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.74 MB

english, 2013

31

Reverse the Diastereoselectivity of the Rh(I)-Catalyzed Pauson-Khand Cycloaddition

Turlington, Mark, Pu, Lin

Journal:

Organic Letters

Year:

2011

Language:

english

File:

PDF, 795 KB

english, 2011

32

SYNTHESIS AND BIOPHYSICAL TESTING OF A NOVEL PYRROLE-CONTAINING POLYAMIDE-BENZAMIDINE HYBRID

Turlington, Mark, Mackay, Hilary, Rutledge, Caleb, Taherbhai, Zarmeen, Nguyen, Binh, Wilson, David, Lee, Moses

Journal:

Heterocyclic Communications

Year:

2006

Language:

english

File:

PDF, 705 KB

english, 2006

33

NOVEL PICOLINIC ACID-CONTAINING PYRROLE-IMIDAZOLE POLYAMIDES: SYNTHESIS AND T-G MISMATCHED BASE PAIR RECOGNITION

Uthe, Peter B., Staples, Andrew M., Turlington, Mark, Jones, Justin B., Blackmon, Kevin N., Bailey, Suzanna L., Buchmueller, Karen L., Lee, Moses

Journal:

Heterocyclic Communications

Year:

2005

Language:

english

File:

PDF, 567 KB

english, 2005

34

Asymmetric Alkyne Addition to Aldehydes Catalyzed by BINOL and Its Derivatives

Turlington, Mark, Pu, Lin

Journal:

Year:

2012

Language:

english

File:

PDF, 838 KB

english, 2012

35

Highly Stereoselective Synthesis of Terminal Chloro-Substituted Propargylamines and Further Functionalization

Jordan, Savannah, Starks, Samuel A., Whatley, Michael F., Turlington, Mark

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 361 KB

english, 2015

36

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 978 KB

english, 2015

37

ChemInform Abstract: Highly Stereoselective Synthesis of Terminal Chloro-Substituted Propargylamines and Further Functionalization.

Jordan, Savannah, Starks, Samuel A., Whatley, Michael F., Turlington, Mark

Journal:

Year:

2016

File:

PDF, 31 KB

2016

38

ChemInform Abstract: Total Synthesis of Stemaphylline N-Oxide (II) and Related C9a-Epimeric Analogues (III) and (IV).

Schulte, Michael L., Turlington, Mark L., Phatak, Sharangdhar S., Harp, Joel M., Stauffer, Shaun R., Lindsley, Craig W.

Journal:

Year:

2014

File:

PDF, 22 KB

2014

39

A flexible method for the synthesis of 2-substituted 1,2,5,6-tetrahydropyridines and piperidines from chloro-containing propargylamines

Penk, Danielle N., Robinson, Nathan A., Hill, Harrison M., Turlington, Mark

Journal:

Tetrahedron Letters

Year:

2017

Language:

english

File:

PDF, 648 KB

english, 2017

40

Structural Consequences of the 1,2,3âTriazole as an Amide Bioisostere in Analogs of Cystic Fibrosis Drugs VXâ809 and VXâ770

Doiron, Jake E., Le, Christina A., Bacsa, John, Breton, Gary W., Martin, Kenneth L., Aller, Stephen G., Turlington, Mark

Journal:

Year:

2020

File:

PDF, 1.54 MB

2020

41

Structural Consequences of the 1,2,3âTriazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VXâ809âand VXâ770

Doiron, Jake E., Le, Christina A., Bacsa, John, Breton, Gary W., Martin, Kenneth L., Aller, Stephen G., Turlington, Mark

Journal:

Year:

2020

File:

PDF, 1.25 MB

2020